We’ve all experienced moments with music that has evoked memories, inspired creativity and celebration, shifted mood, and enhanced motivation and focus. Most of us have also been affected by music while watching a movie–our heart beats racing with the action. People have long been fascinated by these effects of music. From ancient times to modern day, many cultures around the globe have incorporated music into their healing ceremonies and spiritual practices. A real scientific inquiry into the effects that music has on health and behavior seems to have begun in the late 1700s. Around that time there was interest in the effects of a specific six-tone scale on emotional, spiritual, and physical wellbeing. The Solfeggio Frequencies are a scale that has continued to inspire research in the fields of bioenergetics, psychology, immunology, genetics, biology, music therapy, sound healing, and many other disciplines.
Why the Solfeggio Frequencies Matter
The Solfeggio Frequencies are believed to have been in existence since ancient Hindu cultures first began chanting in Sanskrit. The scale came into popularity during the 10th Century when the Solfeggio Frequencies formed the basis for Gregorian Chants (a form of spiritual music that is a hallmark of the early Roman Catholic Church). In modern times, the scale has been incorporated into all manner of spiritual and “healing” music as well as modern vocal music. In fact, the Solfeggio Frequencies are the basis for the Do-Re-Mi-Fa-So-La-Ti scale. But that’s not why the Solfeggio Frequencies matter to health scientists.
The Solfeggio’s six scales were purported to be associated with specific healing attributes:
First Note: 396 Hz liberates feelings of guilt and fear.
Second Note: 417 Hz alleviates the conscious and subconscious mind from traumatic past experiences and facilitates life changes.
Third Note: 528 Hz brings about profound physical transformation.
Fourth Note: 639 Hz improves our connection and relationships with the people around us by healing strained relationships and forming new ones.
Fifth Note: 741 Hz helps us to express ourselves, to open up and share our gifts with the world more fully.
Sixth Note: 852 Hz facilitates a return to spiritual order.
The 6-note Solfeggio was almost lost to history when the 12-note scale was introduced to musicology in the 16th century. It remained alive through the tradition of Gregorian Chants. There wasn’t much, if any, research interest in Solfeggio until the 20th Century when a resurgence of interest in Gregorian Chants intersected with interest in Sanskrit music and sound vibration for use during yoga and meditation practice. This brought about interest in the healing effects of music, in general, as well as specific tunes and vibrations (aka “vibrational healing” and “sound therapy”). One can now find “ambient” music and videos tuned to the Solfeggio Frequencies on YouTube and Spotify.
Studies have since observed the effects of Gregorian Chants, and other music tuned to the Solfeggio Frequencies, on conditions such as autism, depressed mood, and learning disorders. Other scientific areas of inquiry on the Solfeggio include its effect on the nervous system, the endocrine system, the properties of DNA, and even energetic properties of water.
Hospitals have studied the effects of music on how patients heal from surgery. Other studies have examined how music affects people who are in a comatose state and those being treated for serious mental health conditions. Studies have also examined the effects of different types of music on:
Learning and memory
Stress and relaxation response
Mood and emotion
Physiological Effects of Specifically Tuned Music for Healing
Research shows a resounding positive effect of music on learning, social bonding, emotion, and measures of health such as heart rate, blood pressure, and circulating levels of hormones. Various blood tests that measure markers of stress and immunity have shown improvement as a result of listening to music tuned to a specific frequency. There is a unique relationship between stress, music, and immunity, as follows:
Stress, particularly chronic stress, increases the level of the hormone cortisol in the bloodstream. Elevated levels of cortisol suppresses the immune response, making us more prone to illness and chronic diseases. Listening to music tuned to certain frequencies can calm the mind and body enough to lower levels of cortisol and raise the levels of antibodies associated with fighting infection. Additionally, researchers have entrained sound frequencies in different forms of music to align with specific brain wave patterns to bring about relaxation, mental focus, and to promote deeper sleep.
To better understand the clinical significance of the Solfeggio Frequencies, ask your holistic healthcare practitioner for a referral to a music therapist. The following organizations can help you find a music or sound therapist in your area:
International Sound Therapy Association https://ISTASounds.org
The Association of Sound Therapy https://harmonicsounds.com/association-of-sound-therapy/
Sound Healers Association https://www.soundhealersassociation.org
American Music Therapy Association https://www.musictherapy.org
World Federation of Music Therapy https://wfmt.info
ResearchGate.net. “Sound Healing Using Solfeggio Frequencies.” (PDF) Sound Healing using Solfeggio Frequencies
Zacks, J. “Flicker: Your Brain on Movies.” New York: Oxford University Press, 2014.
Chandra, ML. & Levitin, DJ., “The Neurochemistry of Music.” Trends in Cognitive Sciences, (April 2013) 17:4. Accessed Aug 4, 2022:
Goldstein, B. “The Secret Language of the Heart: How to Use Music, Sound, and Vibration as Tools for Healing and Personal Transformation.” Hierophant Publishing, 2016.
https://www.apa.org. “Music as Medicine.” Accessed August 4, 2022.
American Music Therapy Association. “Selected Bibliography on Music Therapy and Mental Health.” Accessed Aug 4, 2022:
“Cortisol: Why the “Stress Hormone” Is Public Enemy No. 1 | Psychology Today.” Accessed May 4, 2017.
North, A.C. and Hargreaves, D.J. “Responses to music in aerobic exercise and yogic relaxation classes.” Br. J. Psychol. (1996) 87, 535–547.
Sloboda, J.A. and O’Neill, S.A. “Emotions in everyday listening to music.” In Music and Emotion: Theory and Research (Juslin, P.N. and Sloboda, J.A., eds) pp. 415–429, Oxford University Press, 2001.
Rickard, N. S. “Intense Emotional Responses to Music: A Test of the Physiological Arousal Hypothesis.” Psychology of Music (2004) 32:4, 371–88.
Brown, S. et al. “Passive music listening spontaneously engages limbic and paralimbic systems.” NeuroReport (2004)15:13, 2033–2037.
Davis, W.B. and Thaut, M.H. “The influence of preferred relaxing music on measures of state anxiety, relaxation, and physiological responses.” J. Music Ther (1989). 26, 168–187.
Khalfa, S. et al., “Effects of relaxing music on salivary cortisol level after psychological stress.” Ann. N. Y. Acad. Sci. (2003) 999, 374–376.